Fetal programming and future disease

Fetal programming and future disease.

Fetal programming of coronary heart disease.

People who develop coronary heart disease grow differently from other people both in utero and during childhood. Slow growth during fetal life and infancy is followed by accelerated weight gain in childhood. Two disorders that predispose to coronary heart disease, type 2 diabetes and hypertension, are preceded by similar paths of growth. Mechanisms underlying this are thought to include the dev...

Adult hypertension and kidney disease: the role of fetal programming.

Hypertension (HTN) and chronic kidney disease are highly prevalent diseases that tend to occur more frequently among disadvantaged populations, in whom prenatal care also tends to be poor. More and more evidence is emerging highlighting the important role of fetal programming in the development of adult disease, suggesting a possible common pathophysiologic denominator in the development of the...

Fetal Programming of the Neuroendocrine-Immune System and Metabolic Disease

Adverse uterine environments experienced during fetal development can alter the projected growth pattern of various organs and systems of the body, leaving the offspring at an increased risk of metabolic disease. The thrifty phenotype hypothesis has been demonstrated as an alteration to the growth trajectory to improve the survival and reproductive fitness of the individual. However, when the i...

Fetal programming of adult kidney disease: cellular and molecular mechanisms.

Fetal Programming of Adult Kidney Disease: Cellular and Molecular Mechanisms Dov Hershkovitz,* Zvi Burbea, Karl Skorecki,* and Barry M. Brenner *Laboratory of Molecular Medicine and Department of Nephrology, Rambam Health Care Campus, and Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel; and Brigham and Women’s Hospital and Harvard Med...